The primary aim is to facilitate an overall well-being for patients suffering from incurable neurological disorders through Neuroregenerative Rehabilitative Therapy (NRRT). In addition to the above, providing support to cellular therapy research & regenerative medicine and increasing awareness about its applications are supplementary objectives.
Some time ago donated organs were transplanted to replace the diseased or failed organs in the recipients. Soon the number of recipients exceeded the number of donated. To overcome this demand, cell therapy offered the possibility of replacement of the damaged cells of tissue with new cells. Stem cell infusion helps to treat a plethora of conditions including cerebral palsy, spinal cord injury, intellectual disability, and other neurodegenerative syndromes as well.
Stem cells have the potential to develop into different cells of the tissues (of the body) and the ability of self-renewal. When serving as a repair system, the stem cells divide without limit as long as the person is alive. As they divide, they remain as stem cells or develop into cells with more specialized functions, like a brain cell or a muscle cell.
Stem cells, from different sources, have three common properties: They can grow into specialized cell types such as nerve cells, muscle cells, and blood cells.
Impairments linked to neuromuscular conditions are usually irreversible due to inadequate cell regeneration or impaired cells in the central nervous system. It was observed that the cellular characteristics of autologous stem cells had the capability of treating major neurological disorders without incurring any side effects. With their neurotrophic properties, self-renewal & differentiation capacity, and immune modulation effects, the bone marrow-derived stem cells are considered as a promising candidate for treating disorders related to the nervous system.
For cell treatment, bone marrow derived mesenchymal stem cells are isolated from the marrow tissue (extracted from the patient’s hip bone) in an expedited, painless and safe way. By centrifugation procedure, a sufficient number of stem cells are separated from the unwanted tissue within a few hours. These injectable stem cells are infused intrathecally into the spinal area or the damaged muscle points, as per the need of the patients.
These bone marrow-derived stem cells have many useful properties that lead to great clinical improvement in post-cell-based therapy. According to various clinical trials, treatment with bone marrow derived mesenchymal stem cells have shown improvement in patients with traumatic brain injury, spinal cord injury and other neurological disorders through axonal sprouting and remyelination, potential to replace/protect the damaged neurons/cells, and neovascularization.
How do the infused stem cells act? Once infused into the body,
– The infused stem cells journey toward the nervous system and blend into the neural circuits to mend or improve the disrupted synaptic transmission.
– Post infusion, improved neuropathological condition, upregulated Aß clearance and reduced deposition is detected within a short period.
– The infused stem cells reduce neuroinflammation and provide protective immunomodulatory effect.
– The stem cells secrete neurotrophic influence and nerve growth factors, bringing cognitive and memory improvement in patients.
Apart from encouraging effects, renewed brain plasticity is also observed in patients following intrathecal delivery of stem cells. With the new medical breakthrough in stem cell therapy, the treatment has become a highly sought-after curative. To know about the treatment efficacy, one must understand the efficiency of stem cells in terms of engraftment, migration, cytokines and growth factors. However, cell-based therapy is a promising contribution to regenerative medicine and has gained considerable clinical attention. Read more info at NeuroGen BSI.
Physical therapy is typically the first, and most important, step toward treating cerebral palsy. It usually begins at a young age and is geared toward improving independent motor function. The types of physical therapies used for children depend on their specific movement problems and symptoms that coincide with cerebral palsy. Before physical therapy begins, the therapist takes an assessment of the child’s motor capabilities. This helps determine the most appropriate measures for therapy. After evaluating the child, the therapist will prescribe strength training exercises, stretches and muscle relaxing techniques based on the child’s needs. Exercise equipment includes weights, resistance bands, balance balls and machines to improve muscle tone. Hot and cold packs are often used to help relax and heal muscles.
A few tricks to help your child with autism: Stick to a schedule. Children with ASD tend to do best when they have a highly-structured schedule or routine. Again, this goes back to the consistency they both need and crave. Set up a schedule for your child, with regular times for meals, therapy, school, and bedtime. Try to keep disruptions to this routine to a minimum. If there is an unavoidable schedule change, prepare your child for it in advance. Reward good behavior. Positive reinforcement can go a long way with children with ASD, so make an effort to “catch them doing something good.” Praise them when they act appropriately or learn a new skill, being very specific about what behavior they’re being praised for. Also look for other ways to reward them for good behavior, such as giving them a sticker or letting them play with a favorite toy.
What’s the long-term outlook? Some people lead full and productive lives after a spinal cord injury. However, there are severe potential effects of a spinal cord injury. The vast majority of people will need assistive devices such as walkers or wheelchairs to deal with loss of mobility, and some may even be paralyzed from the neck down. You may need assistance with daily living activities and learn to perform tasks differently. Pressure sores and urinary tract infections are common complications. You also may expect to undergo intense rehabilitation treatment for your spinal cord injury.
Did you know that the first successful stem cell transplant took place in 1988? That year, doctors used the blood sample from the umbilical cord of a newborn to treat Fanconi’s syndrome, which his 5-year-old brother suffered from. It is estimated that more than 22,000 stem cell transplants from umbilical cord blood have been performed worldwide.
At NeuroGen, along with cell therapy there is a strong emphasis on academic work and clinical research material on stem cell therapy. A detailed analysis of the clinical data is carried out on a regular basis and this is published in various scientific journals. We have vast repertoire of stem cell publications. Currently, 95 scientific papers have been published by our team in various international and national peer reviewed medical journals. We also have 7 chapters in International textbooks and our team has also published over 18 stem cell therapy books. See extra details Stem Cell Research & Therapy.